IUBMB Enzyme Nomenclature


Accepted name: angelicin synthase

Reaction: (+)-columbianetin + [reduced NADPH—hemoprotein reductase] + O2 = angelicin + [oxidized NADPH—hemoprotein reductase] + acetone + 2 H2O

For diagram of reaction click here.

Other name(s): CYP71AJ4 (gene name)

Systematic name: (+)-columbianetin,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase

Comments: This cytochrome P-450 (heme-thiolate) enzyme from wild parsnip is involved in the formation of angular furanocoumarins. Attacks its substrate by syn-elimination of hydrogen from C-3'.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Larbat, R., Hehn, A., Hans, J., Schneider, S., Jugde, H., Schneider, B., Matern, U. and Bourgaud, F. Isolation and functional characterization of CYP71AJ4 encoding for the first P450 monooxygenase of angular furanocoumarin biosynthesis. J. Biol. Chem. 284 (2009) 4776-4785. [PMID: 19098286]

[EC created 2010 as EC, transferred 2018 to EC]

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