IUBMB Enzyme Nomenclature


Accepted name: β-amyrin 16α-hydroxylase

Reaction: β-amyrin + [reduced NADPH—hemoprotein reductase] + O2 = 16α-hydroxy-β-amyrin + [oxidized NADPH—hemoprotein reductase] + H2O

For diagram of reaction click here

Glossary: 16α-hydroxy-β-amyrin = olean-12-ene-3β,16α-diol

Other name(s): CYP87D16

Systematic name: β-amyrin,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (16α-hydroxylating)

Comments: A cytochrome P-450 (heme-thiolate) protein isolated from the plant Maesa lanceolata (false assegai). Involved in the biosynthesis of maesasaponins. It also acts on some derivatives of β-amyrin such as erythrodiol or oleanolic acid.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Moses, T., Pollier, J., Almagro, L., Buyst, D., Van Montagu, M., Pedreño, M.A., Martins, J.C., Thevelein, J.M. and Goossens, A. Combinatorial biosynthesis of sapogenins and saponins in Saccharomyces cerevisiae using a C-16α hydroxylase from Bupleurum falcatum. Proc. Natl Acad. Sci. USA 111 (2014) 1634-1639. [PMID: 24434554]

2. Moses, T., Pollier, J., Faizal, A., Apers, S., Pieters, L., Thevelein, J.M., Geelen, D. and Goossens, A. Unraveling the triterpenoid saponin biosynthesis of the African shrub Maesa lanceolata. Mol. Plant 8 (2015) 122-135. [PMID: 25578277]

[EC created 2019]

Return to EC 1.14.14 home page
Return to EC 1.14 home page
Return to EC 1 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page