Reaction: tryptamine + O2 + [reduced NADPH—hemoprotein reductase] = serotonin + H2O + [oxidized NADPH—hemoprotein reductase]
Glossary: serotonin = 5-hydroxytryptamine
Other name(s): CYP71P1 (gene name)
Systematic name: tryptamine,NADPH—hemoprotein reductase:oxygen oxidoreductase (5-hydroxylating)
Comments: A cytochrome P-450. The enzyme has been characterized from rice (Oryza sativa) and walnut (Juglans regia).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Schroder, P., Abele, C., Gohr, P., Stuhlfauth-Roisch, U. and Grosse, W. Latest on enzymology of serotonin biosynthesis in walnut seeds. Adv. Exp. Med. Biol. 467 (1999) 637-644. [PMID: 10721112]
2. Fujiwara, T., Maisonneuve, S., Isshiki, M., Mizutani, M., Chen, L., Wong, H.L., Kawasaki, T. and Shimamoto, K. Sekiguchi lesion gene encodes a cytochrome P450 monooxygenase that catalyzes conversion of tryptamine to serotonin in rice. J. Biol. Chem. 285 (2010) 11308-11313. [PMID: 20150424]
3. Park, S., Kang, K., Lee, S.W., Ahn, M.J., Bae, J.M. and Back, K. Production of serotonin by dual expression of tryptophan decarboxylase and tryptamine 5-hydroxylase in Escherichia coli. Appl. Microbiol. Biotechnol. 89 (2011) 1387-1394. [PMID: 21080162]
4. Park, S., Byeon, Y. and Back, K. Transcriptional suppression of tryptamine 5-hydroxylase, a terminal serotonin biosynthetic gene, induces melatonin biosynthesis in rice (Oryza sativa L.). J Pineal Res 55 (2013) 131-137. [PMID: 23521226]