IUBMB Enzyme Nomenclature

EC 1.14.14.187

Accepted name: rhazimal synthase

Reaction: geissoschizine + [reduced NADPH—hemoprotein reductase] + O2 = rhazimal + [oxidized NADPH—hemoprotein reductase] + 2 H2O

For diagram of reaction click here and mechanism click here

Other name(s): RHS (gene name)

Systematic name: geissoschizine,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (rhazimal forming)

Comments: A heme-thiolate protein (P-450) isolated from the plant Alstonia scholaris (blackboard tree).

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:

References:

1. Wang, Z., Xiao, Y., Wu, S., Chen, J., Li, A. and Tatsis, E.C. Deciphering and reprogramming the cyclization regioselectivity in bifurcation of indole alkaloid biosynthesis. Chem. Sci. 13 (2022) 12389-12395. [PMID: 36349266]

[EC 1.14.14.187 created 2024]


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