Reaction: geissoschizine + [reduced NADPH—hemoprotein reductase] + O2 = rhazimal + [oxidized NADPH—hemoprotein reductase] + 2 H2O
For diagram of reaction click here and mechanism click here
Other name(s): RHS (gene name)
Systematic name: geissoschizine,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (rhazimal forming)
Comments: A heme-thiolate protein (P-450) isolated from the plant Alstonia scholaris (blackboard tree).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Wang, Z., Xiao, Y., Wu, S., Chen, J., Li, A. and Tatsis, E.C. Deciphering and reprogramming the cyclization regioselectivity in bifurcation of indole alkaloid biosynthesis. Chem. Sci. 13 (2022) 12389-12395. [PMID: 36349266]