IUBMB Enzyme Nomenclature


Accepted name: dimethylsulfone monooxygenase

Reaction: dimethyl sulfone + FMNH2 + O2 = methanesulfinate + formaldehyde + FMN + H2O

Other name(s): sfnG (gene name)

Systematic name: dimethyl sulfone,FMNH2:oxygen oxidoreductase

Comments: The enzyme, characterized from Pseudomonas spp., is involved in a dimethyl sulfide degradation pathway. It is dependent on NAD(P)H-dependent FMN reductase (EC, EC, or EC, which provides it with reduced FMN. The product, methanesulfinate, is oxidized spontaneously to methanesulfonate in the presence of dioxygen and FMNH2.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Endoh, T., Habe, H., Nojiri, H., Yamane, H. and Omori, T. The σ54-dependent transcriptional activator SfnR regulates the expression of the Pseudomonas putida sfnFG operon responsible for dimethyl sulphone utilization. Mol. Microbiol. 55 (2005) 897-911. [PMID: 15661012]

2. Wicht, D.K. The reduced flavin-dependent monooxygenase SfnG converts dimethylsulfone to methanesulfinate. Arch. Biochem. Biophys. 604 (2016) 159-166. [PMID: 27392454]

[EC created 2016]

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