IUBMB Enzyme Nomenclature


Accepted name: alkanesulfonate monooxygenase

Reaction: an alkanesulfonate + FMNH2 + O2 = an aldehyde + FMN + sulfite + H2O

Glossary: an alkanesulfonate = R-CH2-SO3-
an aldehyde = R-CHO

Other name(s): SsuD; sulfate starvation-induced protein 6; alkanesulfonate,reduced-FMN:oxygen oxidoreductase

Systematic name: alkanesulfonate,FMNH2:oxygen oxidoreductase

Comments: The enzyme from Escherichia coli catalyses the desulfonation of a wide range of aliphatic sulfonates (unsubstituted C1- to C14-sulfonates as well as substituted C2-sulfonates). Does not desulfonate taurine (2-aminoethanesulfonate) or aromatic sulfonates. Does not use FMN as a bound cofactor. Instead, it uses reduced FMN (i.e., FMNH2) as a substrate. FMNH2 is provided by SsuE, the associated FMN reductase (EC

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 256383-67-2


1. Eichhorn, E., van der Ploeg, J.R. and Leisinger, T. Characterization of a two-component alkanesulfonate monooxygenase from Escherichia coli. J. Biol. Chem. 274 (1999) 26639-26646. [PMID: 10480865]

[EC created 2002]

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