Reaction: (S)-limonene + [reduced NADPH hemoprotein reductase] + O2 = ()-trans-carveol + [oxidized NADPH hemoprotein reductase] + H2O
For diagram of reaction click here
Glossary: limonene = a monoterpenoid
(S)-limonene = ()-limonene
Other name(s): ()-limonene 6-hydroxylase; ()-limonene 6-monooxygenase; ()-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating)
Systematic name: (S)-limonene,[reduced NADPH hemoprotein reductase]:oxygen oxidoreductase (6-hydroxylating)
Comments: A cytochrome P-450 (heme thiolate) enzyme. The enzyme participates in the biosynthesis of ()-carvone, which is responsible for the aroma of spearmint.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Karp, F., Mihaliak, C.A., Harris, J.L. and Croteau, R. Monoterpene biosynthesis: specificity of the hydroxylations of ()-limonene by enzyme preparations from peppermint (Mentha piperita), spearmint (Mentha spicata), and perilla (Perilla frutescens) leaves. Arch. Biochem. Biophys. 276 (1990) 219-226. [PMID: 2297225]