IUBMB Enzyme Nomenclature


Accepted name: (S)-limonene 6-monooxygenase

Reaction: (S)-limonene + [reduced NADPH —hemoprotein reductase] + O2 = (–)-trans-carveol + [oxidized NADPH —hemoprotein reductase] + H2O

For diagram of reaction click here

Glossary: limonene = a monoterpenoid
(S)-limonene = (–)-limonene

Other name(s): (–)-limonene 6-hydroxylase; (–)-limonene 6-monooxygenase; (–)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating)

Systematic name: (S)-limonene,[reduced NADPH —hemoprotein reductase]:oxygen oxidoreductase (6-hydroxylating)

Comments: A cytochrome P-450 (heme thiolate) enzyme. The enzyme participates in the biosynthesis of (–)-carvone, which is responsible for the aroma of spearmint.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Karp, F., Mihaliak, C.A., Harris, J.L. and Croteau, R. Monoterpene biosynthesis: specificity of the hydroxylations of (–)-limonene by enzyme preparations from peppermint (Mentha piperita), spearmint (Mentha spicata), and perilla (Perilla frutescens) leaves. Arch. Biochem. Biophys. 276 (1990) 219-226. [PMID: 2297225]

[EC created 1992 as EC, modified 2003, transferred 2017 to EC]

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