IUBMB Enzyme Nomenclature


Accepted name: (R)-limonene 6-monooxygenase

Reaction: (R)-limonene + [reduced NADPH —hemoprotein reductase] + O2 = (+)-trans-carveol + [oxidized NADPH —hemoprotein reductase] + H2O

For diagram of reaction click here

Glossary: limonene = a monoterpenoid
(R)-limonene = (+)-limonene

Other name(s): (+)-limonene-6-hydroxylase; (+)-limonene 6-monooxygenase

Systematic name: (R)-limonene,[reduced NADPH —hemoprotein reductase]:oxygen oxidoreductase (6-hydroxylating)

Comments: The reaction is stereospecific with over 95% yield of (+)-trans-carveol from (R)-limonene. (S)-Limonene, the substrate for EC, (S)-limonene 6-monooxygenase, is not a substrate. Forms part of the carvone biosynthesis pathway in Carum carvi (caraway) seeds.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Bouwmeester, H.J., Gershenzon, J., Konings, M.C.J.M. and Croteau, R. Biosynthesis of the monoterpenes limonene and carvone in the fruit of caraway. I. Demonstration of enzyme activities and their changes with development. Plant Physiol. 117 (1998) 901-912. [PMID: 9662532]

2. Bouwmeester, H.J., Konings, M.C.J.M., Gershenzon, J., Karp, F. and Croteau, R. Cytochrome P-450 dependent (+)-limonene-6-hydroxylation in fruits of caraway (Carum carvi). Phytochemistry 50 (1999) 243-248.

[EC created 2003 as EC, transferred 2017 to EC]

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