IUBMB Enzyme Nomenclature


Accepted name: β-amyrin 16β-monooxygenase

Reaction: β-amyrin + [reduced NADPH—hemoprotein reductase] + O2 = maniladiol + [oxidized NADPH—hemoprotein reductase] + H2O

For diagram of reaction click here.

Glossary: cochalic acid = 3β,16β-dihydroxyolean-12-en-28-oic acid
maniladiol = 16β-hydroxy-β-amyrin = olean-12-ene-3β,16β-diol

Other name(s): CYP716A141

Systematic name: β-amyrin,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (maniladiol forming)

Comments: A cytochrome P-450 (heme-thiolate) protein isolated from the plant Platycodon grandiflorus (baloon flower). The enzyme is also able to oxidize oleanolic acid to cochalic acid.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Tamura, K., Teranishi, Y., Ueda, S., Suzuki, H., Kawano, N., Yoshimatsu, K., Saito, K., Kawahara, N., Muranaka, T. and Seki, H. Cytochrome P450 monooxygenase CYP716A141 is a unique β-amyrin C-16β oxidase Involved in triterpenoid saponin biosynthesis in Platycodon grandiflorus. Plant Cell Physiol 58 (2017) 874-884. [PMID: 28371833]

[EC created 2018]

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