IUBMB Enzyme Nomenclature


Accepted name: cucurbitadienol 11-hydroxylase

Reaction: cucurbitadienol + 2 [reduced NADPH—hemoprotein reductase] + 2 O2 = 11-oxocucurbitadienol + 2 [oxidized NADPH—hemoprotein reductase] + 3 H2O (overall reaction) (26 April 2018)
(1a) cucurbitadienol + [reduced NADPH—hemoprotein reductase] + O2 = 11-hydroxycucurbitadienol + [oxidized NADPH—hemoprotein reductase] + H2O
(1b) 11-hydroxycucurbitadienol + [reduced NADPH—hemoprotein reductase] + O2 = 11-oxocucurbitadienol + [oxidized NADPH—hemoprotein reductase] + 2 H2O

For diagram of reaction click here.

Glossary: 11-oxocucurbitadienol = 3β-hydroxycucurbita-7,24-dien-11-one

Other name(s): CYP87D18

Systematic name: cucurbitadienol,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (11-oxocucurbitadienol forming)

Comments: Isolated from the plant Siraitia grosvenorii (monk fruit).

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Zhang, J., Dai, L., Yang, J., Liu, C., Men, Y., Zeng, Y., Cai, Y., Zhu, Y. and Sun, Y. Oxidation of cucurbitadienol catalyzed by CYP87D18 in the biosynthesis of mogrosides from Siraitia grosvenorii. Plant Cell Physiol 57 (2016) 1000-1007. [PMID: 26903528]

[EC created 2018]

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