IUBMB Enzyme Nomenclature


Accepted name: anthranilate 3-monooxygenase (FAD)

Reaction: anthranilate + FADH2 + O2 = 3-hydroxyanthranilate + FAD + H2O

Glossary: anthranilate = 2-aminobenzoate

Other name(s): anthranilate 3-hydroxylase; anthranilate hydroxylase

Systematic name: anthranilate,FADH2:oxygen oxidoreductase (3-hydroxylating)

Comments: This enzyme, isolated from the bacterium Geobacillus thermodenitrificans, participates in the pathway of tryptophan degradation. The enzyme is part of a system that also includes a bifunctional riboflavin kinase/FMN adenylyltransferase and an FAD reductase, which ensures ample supply of FAD to the monooxygenase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Liu, X., Dong, Y., Li, X., Ren, Y., Li, Y., Wang, W., Wang, L. and Feng, L. Characterization of the anthranilate degradation pathway in Geobacillus thermodenitrificans NG80-2. Microbiology 156 (2010) 589-595. [PMID: 19942660]

[EC created 2010]

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