IUBMB Enzyme Nomenclature


Accepted name: 7-deoxyloganate 7-hydroxylase

Reaction: 7-deoxyloganate + [reduced NADPH—hemoprotein reductase] + O2 = loganate + [oxidized NADPH—hemoprotein reductase] + H2O

For diagram of reaction click here

Glossary: logonate = (1S,4aS,6S,7R,7aS)-1-(β-D-glucopyranosyloxy)-6-hydroxy-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate

Other name(s): CYP72A224 (gene name); 7-deoxyloganin 7-hydroxylase (incorrect); 7-deoxyloganin,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (7α-hydroxylating) (incorrect)

Systematic name: 7-deoxyloganate,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (7α-hydroxylating)

Comments: The enzyme, characterized from the plant Catharanthus roseus, is a cytochrome P-450 (heme-thiolate) enzyme. It catalyses a reaction in the pathway leading to biosynthesis of monoterpenoid indole alkaloids.

Links to other databases: BRENDA, EXPASY, ExplorEnz, KEGG, MetaCyc, CAS registry number: 335305-40-3


1. Katano, N., Yamamoto, H., Iio, R. and Inoue, K. 7-Deoxyloganin 7-hydroxylase in Lonicera japonica cell cultures. Phytochemistry 58 (2001) 53-58. [PMID: 11524113]

2. Miettinen, K., Dong, L., Navrot, N., Schneider, T., Burlat, V., Pollier, J., Woittiez, L., van der Krol, S., Lugan, R., Ilc, T., Verpoorte, R., Oksman-Caldentey, K.M., Martinoia, E., Bouwmeester, H., Goossens, A., Memelink, J. and Werck-Reichhart, D. The seco-iridoid pathway from Catharanthus roseus. Nat Commun 5 (2014) 3606. [PMID: 24710322]

[EC created 2002 as EC, transferred 2018 to EC, modified 2018]

Return to EC 1.14.14 home page
Return to EC 1.14 home page
Return to EC 1 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page