IUBMB Enzyme Nomenclature


Accepted name: benzoate 4-monooxygenase

Reaction: benzoate + [reduced NADPH—hemoprotein reductase] + O2 = 4-hydroxybenzoate + [oxidized NADPH—hemoprotein reductase] + H2O

For diagram of reaction click here.

Other name(s): benzoic acid 4-hydroxylase; benzoate 4-hydroxylase; benzoic 4-hydroxylase; benzoate-p-hydroxylase; p-hydroxybenzoate hydroxylase; CYP53A1 (gene name)

Systematic name: benzoate,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (4-hydroxylating)

Comments: A cytochrome P-450 (heme-thiolate) protein found in Aspergillus fungi.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Reddy, C.C. and Vaidyanathan, C.S. Purification, properties and induction of a specific benzoate-4-hydroxylase from Aspergillus niger (UBC 814). Biochim. Biophys. Acta 384 (1975) 46-57. [PMID: 236777]

2. Faber, B.W., van Gorcom, R.F. and Duine, J.A. Purification and characterization of benzoate-para-hydroxylase, a cytochrome P450 (CYP53A1), from Aspergillus niger. Arch. Biochem. Biophys. 394 (2001) 245-254. [PMID: 11594739]

[EC created 1976 as EC, transferred 2018 to EC]

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