IUBMB Enzyme Nomenclature


Accepted name: calcidiol 1-monooxygenase

Reaction: calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitriol + 2 oxidized adrenodoxin + H2O

For diagram of reaction click here.

Glossary: calcidiol = 25-hydroxyvitamin D3 = (3S,5Z,7E)-9,10-seco-5,7,10(19)-cholestatriene-3,25-diol
calcitriol = 1α,25-dihydroxyvitamin D3 = (1S,3R,5Z,7E)-9,10-seco-5,7,10(19)-cholestatriene-1,3,25-triol

Other name(s): 25-hydroxycholecalciferol 1-hydroxylase; 25-hydroxycholecalciferol 1-monooxygenase; 1-hydroxylase-25-hydroxyvitamin D3; 25-hydroxy D3-1α-hydroxylase; 25-hydroxycholecalciferol 1α-hydroxylase; 25-hydroxyvitamin D3 1α-hydroxylase

Systematic name: calcidiol,adrenodoxin:oxygen oxidoreductase (1-hydroxylating)

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Gray, R.W., Omdahl, J.L., Ghazarian, J.G. and De Luca, H.F. 25-Hydroxycholecalciferol-1-hydroxylase. Subcellular location and properties. J. Biol. Chem. 247 (1972) 7528-7532. [PMID: 4404596]

[EC created 1976 as EC, transferred 2016 to EC]

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