IUBMB Enzyme Nomenclature


Accepted name: icosanoyl-CoA 5-desaturase

Reaction: icosanoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = (Z)-icos-5-enoyl-CoA + 2 ferricytochrome b5 + 2 H2O

Other name(s): acyl-CoA Δ5-desaturase (ambiguous)

Systematic name: icosanoyl-CoA,ferrocytochrome b5:oxygen oxidoreductase (5,6 cis-dehydrogenating)

Comments: The enzyme, characterized from the plant Limnanthes douglasii (meadowfoam), is involved in the biosynthesis of (5Z)-icos-5-enoate, an unusual monounsaturated fatty acid that makes up to 60% of the total fatty acids in Limnanthes sp. seed oil. The enzyme only acts on saturated fatty acids.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Cahoon, E.B., Marillia, E.F., Stecca, K.L., Hall, S.E., Taylor, D.C. and Kinney, A.J. Production of fatty acid components of meadowfoam oil in somatic soybean embryos. Plant Physiol. 124 (2000) 243-251. [PMID: 10982439]

[EC created 2015]

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