Reaction: (R)-reticuline + [reduced NADPHhemoprotein reductase] + O2 = salutaridine + [oxidized NADPHhemoprotein reductase] + 2 H2O
For diagram of reaction click here.
Other name(s): (R)-reticuline oxidase (C-C phenol-coupling)
Systematic name: (R)-reticuline,[reduced NADPHhemoprotein reductase]:oxygen oxidoreductase (C-C phenol-coupling)
Comments: A cytochrome P-450 (heme-thiolate) protein found in plants. Forms the morphinan alkaloid salutaridine by intramolecular phenol oxidation of reticuline without the incorporation of oxygen into the product.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
1. Gerady, R. and Zenk, M.H. Formation of salutaridine from (R)-reticuline by a membrane-bound cytochrome P-450 enzyme from Papaver somniferum. Phytochemistry 32 (1993) 79-86.