Reaction: (19E)-geissoschizine + [oxidized NADPH—hemoprotein reductase] + O2 = polyneuridine aldehyde + [reduced NADPH—hemoprotein reductase] + 2 H2O
For diagram of reaction click here
Other name(s): SBE (gene name); sarpagan bridge enzyme; CYP71AY4; CYP71AY5
Systematic name: (19E)-geissoschizine:[oxidized NADPH—hemoprotein reductase] oxidoreductase (polyneuridine aldehyde forming)
Comments: A heme-thiolate protein (P-450). The enzyme, characterized from the plants Rauwolfia serpentina (Indian snakeroot) and Gelsemium sempervirens (yellow jessamine), is involved in the biosynthesis of monoterpenoid indole alkaloids of the sarpagan, ajmalan and alstophyllan classes.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Dang, T.T., Franke, J., Carqueijeiro, I.ST., Langley, C., Courdavault, V. and O'Connor, S.E. Sarpagan bridge enzyme has substrate-controlled cyclization and aromatization modes. Nat. Chem. Biol. 14 (2018) 760-763. [PMID: 29942076]