IUBMB Enzyme Nomenclature

EC 1.14.19.81

Accepted name: polyneuridine aldehyde synthase

Reaction: (19E)-geissoschizine + [oxidized NADPH—hemoprotein reductase] + O2 = polyneuridine aldehyde + [reduced NADPH—hemoprotein reductase] + 2 H2O

For diagram of reaction click here

Other name(s): SBE (gene name); sarpagan bridge enzyme; CYP71AY4; CYP71AY5

Systematic name: (19E)-geissoschizine:[oxidized NADPH—hemoprotein reductase] oxidoreductase (polyneuridine aldehyde forming)

Comments: A heme-thiolate protein (P-450). The enzyme, characterized from the plants Rauwolfia serpentina (Indian snakeroot) and Gelsemium sempervirens (yellow jessamine), is involved in the biosynthesis of monoterpenoid indole alkaloids of the sarpagan, ajmalan and alstophyllan classes.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:

References:

1. Dang, T.T., Franke, J., Carqueijeiro, I.ST., Langley, C., Courdavault, V. and O'Connor, S.E. Sarpagan bridge enzyme has substrate-controlled cyclization and aromatization modes. Nat. Chem. Biol. 14 (2018) 760-763. [PMID: 29942076]

[EC 1.14.19.81 created 2024]


Return to EC 1.14.19 home page
Return to EC 1.14 home page
Return to EC 1 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page