Reaction: 4α,5β-5,20-epoxytax-11-ene-4,9-diol + 2-oxoglutarate + O2 = 4-hydroxy-4α,5β-5,20-epoxytax-11-en-9-one + succinate + CO2 + H2O
Other name(s): T9α oxidase
Systematic name: 4α,5β-5,20-epoxytax-11-ene-4,9-diol,2-oxoglutarate:oxygen 9-oxidoreductase
Comments: The enzyme is active in the biosynthetic pathway of paclitaxel (Taxol) in Taxus species (yew).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Zhang, Y., Wiese, L., Fang, H., Alseekh, S., Perez de Souza, L., Scossa, F., Molloy, J., Christmann, M. and Fernie, A.R. Synthetic biology identifies the minimal gene set required for paclitaxel biosynthesis in a plant chassis. Mol. Plant 16 (2023) 1951-1961. [PMID: 37897038]