Reaction: estradiol-17β + reduced acceptor + O2 = 6β-hydroxyestradiol-17β + acceptor + H2O
Other name(s): estradiol 6β-hydroxylase
Systematic name: estradiol-17β,hydrogen-donor:oxygen oxidoreductase (6β-hydroxylating)
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 9029-70-3
References:
1. Haines, W.J. The biosynthesis of adrenal cortex hormones. Recent Progr. Hormone Res. 7 (1952) 255-305.
2. Mueller, G.C. and Rumney, G. Formation of 6β-hydroxy and 6-keto derivatives of estradiol-16-C14 by mouse liver microsomes. J. Am. Chem. Soc. 79 (1957) 1004-1005.