IUBMB Enzyme Nomenclature


Accepted name: ammonia monooxygenase

Reaction: NH3 + a reduced acceptor + O2 = NH2OH + an acceptor + H2O

Other name(s): AMO

Systematic name: ammonia,donor:oxygen oxidoreductase (hydroxylamine-producing)

Comments: Contains copper and possibly nonheme iron. The donor is membrane-bound. Electrons are derived indirectly from ubiquinol.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Hyman, M.R., Page, C.L. and Arp, D.J. Oxidation of methyl fluoride and dimethyl ether by ammonia monooxygenase in Nitrosomonas europaea. Appl. Environ. Microbiol. 60 (1994) 3033-3035. [PMID: 8085841]

2. Bergmann, D.J. and Hooper, A.B. Sequence of the gene, amoB, for the 43-kDa polypeptide of ammonia monoxygenase of Nitrosomonas europaea. Biochem. Biophys. Res. Commun. 204 (1994) 759-762. [PMID: 7980540]

3. Holmes, A.J., Costello, A., Lidstrom, M.E. and Murrell, J.C. Evidence that particulate methane monooxygenase and ammonia monooxygenase may be evolutionarily related. FEMS Microbiol. Lett. 132 (1995) 203-208. [PMID: 7590173]

4. Zahn, J.A., Arciero, D.M., Hooper, A.B. and DiSpirito, A.A. Evidence for an iron center in the ammonia monooxygenase from Nitrosomonas europaea. FEBS Lett. 397 (1996) 35-38. [PMID: 8941709]

5. Moir, J.W., Crossman, L.C., Spiro, S. and Richardson, D.J. The purification of ammonia monooxygenase from Paracoccus denitrificans. FEBS Lett. 387 (1996) 71-74. [PMID: 8654570]

6. Whittaker, M., Bergmann, D., Arciero, D. and Hooper, A.B. Electron transfer during the oxidation of ammonia by the chemolithotrophic bacterium Nitrosomonas europaea. Biochim. Biophys. Acta 1459 (2000) 346-355. [PMID: 11004450]

7. Arp, D.J., Sayavedra-Soto, L.A. and Hommes, N.G. Molecular biology and biochemistry of ammonia oxidation by Nitrosomonas europaea. Arch. Microbiol. 178 (2002) 250-255. [PMID: 12209257]

8. Gilch, S., Meyer, O. and Schmidt, I. A soluble form of ammonia monooxygenase in Nitrosomonas europaea. Biol. Chem. 390 (2009) 863-873. [PMID: 19453274]

9. Rasche, M.E., Hicks, R.E., Hyman, M.R. and Arp, D.J. Oxidation of monohalogenated ethanes and n-chlorinated alkanes by whole cells of Nitrosomonas europaea. J. Bacteriol. 172 (1990) 5368-5373. [PMID: 2394686]

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