IUBMB Enzyme Nomenclature


Accepted name: diapolycopene oxygenase

Reaction: 4,4'-diapolycopene + 4 reduced acceptor + 4 O2 = 4,4'-diapolycopenedial + 4 acceptor + 6 H2O

For diagram of reaction click here.

Other name(s): crtP (ambiguous)

Systematic name: 4,4'-diapolycopene,AH2:oxygen oxidoreductase (4,4'-hydroxylating)

Comments: Little activity with neurosporene or lycopene. Involved in the biosynthesis of C30 carotenoids such as staphyloxanthin. The enzyme oxidizes each methyl group to the hydroxymethyl and then a dihydroxymethyl group, followed by the spontaneous loss of water to give an aldehyde group.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Mijts, B.N., Lee, P.C. and Schmidt-Dannert, C. Identification of a carotenoid oxygenase synthesizing acyclic xanthophylls: combinatorial biosynthesis and directed evolution. Chem. Biol. 12 (2005) 453-460. [PMID: 15850982]

2. Tao, L., Schenzle, A., Odom, J.M. and Cheng, Q. Novel carotenoid oxidase involved in biosynthesis of 4,4'-diapolycopene dialdehyde. Appl. Environ. Microbiol. 71 (2005) 3294-3301. [PMID: 15933032]

[EC created 2011]

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