IUBMB Enzyme Nomenclature


Accepted name: tryptamine 4-monooxygenase

Reaction: tryptamine + reduced acceptor + O2 = 4-hydroxytryptamine + acceptor + H2O

For diagram of reaction click here

Glossary: psilocybin = 3-[2-(dimethylamino)ethyl]-1H-indol-4-yl phosphate

Other name(s): PsiH

Systematic name: tryptamine,hydrogen-donor:oxygen oxidoreductase (4-hydroxylating)

Comments: A cytochrome P-450 (heme-thiolate) protein isolated from the fungus Psilocybe cubensis. Involved in the biosynthesis of the psychoactive compound psilocybin.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Fricke, J., Blei, F. and Hoffmeister, D. Enzymatic synthesis of psilocybin. Angew. Chem. Int. Ed. Engl. 56 (2017) 12352-12355. [PMID: 28763571]

[EC created 2017]

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