Reaction: Hg + NADP+ + H+ = Hg2+ + NADPH
Other name(s): mercuric reductase; mercurate(II) reductase; mercuric ion reductase; mercury reductase; reduced NADP:mercuric ion oxidoreductase; mer A
Systematic name: Hg:NADP+ oxidoreductase
Comments: A dithiol enzyme.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, UM-BBD, CAS registry number: 67880-93-7
References:
1. Fox, B.S. and Walsh, C.T. Mercuric reductase. Purification and characterization of a transposon-encoded flavoprotein containing an oxidation-reduction-active disulfide. J. Biol. Chem. 257 (1982) 2498-2503. [PMID: 6277900]
2. Fox, B.S. and Walsh, C.T. Mercuric reductase - homology to glutathione-reductase and lipoamide dehydrogenase - iodoacetamide alkylation and sequence of the active-site peptide. Biochemistry 22 (1983) 4082-4088.