IUBMB Enzyme Nomenclature


Accepted name: formate dehydrogenase

Reaction: formate + NAD+ = CO2 + NADH

Other name(s): formate-NAD+ oxidoreductase; FDH I; FDH II; N-FDH; formic hydrogen-lyase; formate hydrogenlyase; hydrogenlyase; NAD+-linked formate dehydrogenase; NAD+-dependent formate dehydrogenase; formate dehydrogenase (NAD+); NAD+-formate dehydrogenase; formate benzyl-viologen oxidoreductase; formic acid dehydrogenase

Systematic name: formate:NAD+ oxidoreductase

Comments: The enzyme from most aerobic organisms is devoid of redox-active centres but that from the proteobacterium Methylosinus trichosporium contains iron-sulfur centres, flavin and a molybdenum centre [3]. Together with EC hydrogen dehydrogenase, forms a system previously known as formate hydrogenlyase.

Links to other databases: BRENDA, EXPASY, GTD, KEGG, MetaCyc, CAS registry number:


1. Davison, D.C. Studies on plant formic dehydrogenase. Biochem. J. 49 (1951) 520-526. [PMID: 14886318]

2. Quayle, J.R. Formate dehydrogenase. Methods Enzymol. 9 (1966) 360-364.

3. Jollie, D.R. and Lipscomb, J.D. Formate dehydrogenase from Methylosinus trichosporium OB3b. Purification and spectroscopic characterization of the cofactors. J. Biol. Chem. 266 (1991) 21853-21863. [PMID: 1657982]

[EC created 1961 as EC, transferred 2017 to EC]

Return to EC 1.17.1 home page
Return to EC 1.17 home page
Return to EC 1 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page