IUBMB Enzyme Nomenclature


Accepted name: formate dehydrogenase (NAD+, ferredoxin)

Reaction: 2 formate + NAD+ + 2 oxidized ferredoxin [iron-sulfur] cluster = 2 CO2 + NADH + H+ + 2 reduced ferredoxin [iron-sulfur] cluster

Other name(s): electron-bifurcating formate dehydrogenase

Systematic name: formate:NAD+, ferredoxin oxidoreductase

Comments: The enzyme complex, isolated from the bacterium Gottschalkia acidurici, couples the reduction of NAD+ and the reduction of ferredoxin with formate via flavin-based electron bifurcation.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Wang, S., Huang, H., Kahnt, J. and Thauer, R.K. Clostridium acidurici electron-bifurcating formate dehydrogenase. Appl. Environ. Microbiol. 79 (2013) 6176-6179. [PMID: 23872566]

[EC created 2015 as EC, transferred 2017 to EC]

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