IUBMB Enzyme Nomenclature


Accepted name: lupanine 17-hydroxylase (cytochrome c)

Reaction: lupanine + 2 ferricytochrome c + H2O = 17-hydroxylupanine + 2 ferrocytochrome c + 2 H+

Other name(s): lupanine dehydrogenase (cytochrome c)

Systematic name: lupanine:cytochrome c-oxidoreductase (17-hydroxylating)

Comments: The enzyme isolated from Pseudomonas putida contains heme c and requires pyrroloquinoline quinone (PQQ) for activity

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Hopper, D.J., Rogozinski, J. and Toczko, M. Lupanine hydroxylase, a quinocytochrome c from an alkaloid-degrading Pseudomonas sp. Biochem. J. 279 (1991) 105-109. [PMID: 1656935]

2. Hopper, D.J. and Kaderbhai, M.A. The quinohaemoprotein lupanine hydroxylase from Pseudomonas putida. Biochim. Biophys. Acta 1647 (2003) 110-115. [PMID: 12686118]

[EC created 2012]

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