IUBMB Enzyme Nomenclature


Accepted name: formate dehydrogenase (cytochrome-c-553)

Reaction: formate + 2 ferricytochrome c-553 = CO2 + 2 ferrocytochrome c-553 + H+

Systematic name: formate:ferricytochrome-c-553 oxidoreductase

Comments: The enzyme has been characterized from the bacterium Desulfovibrio vulgaris. In vitro, yeast cytochrome c, ferricyanide and phenazine methosulfate can act as acceptors.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Yagi, T. Formate: cytochrome oxidoreductase of Desulfovibrio vulgaris. J. Biochem. (Tokyo) 66 (1969) 473-478. [PMID: 4982127]

2. Yagi, T. Purification and properties of cytochrome c-553, an electron acceptor for formate dehydrogenase of Desulfovibrio vulgaris, Miyazaki. Biochim. Biophys. Acta 548 (1979) 96-105. [PMID: 226135]

[EC created 1981 as EC, transferred 2017 to EC]

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