IUBMB Enzyme Nomenclature


Accepted name: caffeine dehydrogenase

Reaction: caffeine + ubiquinone + H2O = 1,3,7-trimethylurate + ubiquinol

Glossary: caffeine = 1,3,7-trimethylxanthine

Systematic name: caffeine:ubiquinone oxidoreductase

Comments: This enzyme, characterized from the soil bacterium Pseudomonas sp. CBB1, catalyses the incorporation of an oxygen atom originating from a water molecule into position C-8 of caffeine. The enzyme utilizes short-tail ubiquinones as the preferred electron acceptor.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Yu, C.L., Kale, Y., Gopishetty, S., Louie, T.M. and Subramanian, M. A novel caffeine dehydrogenase in Pseudomonas sp. strain CBB1 oxidizes caffeine to trimethyluric acid. J. Bacteriol. 190 (2008) 772-776. [PMID: 17981969]

[EC created 2010]

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