IUBMB Enzyme Nomenclature


Accepted name: formate dehydrogenase-N

Reaction: formate + a quinone = CO2 + a quinol

Other name(s): Fdh-N; FdnGHI; nitrate-inducible formate dehydrogenase; formate dehydrogenase N; FDH-N; nitrate inducible Fdn; nitrate inducible formate dehydrogenase

Systematic name: formate:quinone oxidoreductase

Comments: The enzyme contains molybdopterin-guanine dinucleotides, five [4Fe-4S] clusters and two heme b groups. Formate dehydrogenase-N oxidizes formate in the periplasm, transferring electrons via the menaquinone pool in the cytoplasmic membrane to a dissimilatory nitrate reductase (EC, which transfers electrons to nitrate in the cytoplasm. The system generates proton motive force under anaerobic conditions [3].

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Enoch, H.G. and Lester, R.L. The purification and properties of formate dehydrogenase and nitrate reductase from Escherichia coli. J. Biol. Chem. 250 (1975) 6693-6705. [PMID: 1099093]

2. Jormakka, M., Tornroth, S., Byrne, B. and Iwata, S. Molecular basis of proton motive force generation: structure of formate dehydrogenase-N. Science 295 (2002) 1863-1868. [PMID: 11884747]

3. Jormakka, M., Tornroth, S., Abramson, J., Byrne, B. and Iwata, S. Purification and crystallization of the respiratory complex formate dehydrogenase-N from Escherichia coli. Acta Crystallogr. D Biol. Crystallogr. 58 (2002) 160-162. [PMID: 11752799]

[EC created 2010 as EC, transferred 2017 to EC]

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