IUBMB Enzyme Nomenclature


Accepted name: ethylbenzene hydroxylase

Reaction: ethylbenzene + H2O + acceptor = (S)-1-phenylethanol + reduced acceptor

For diagram click here.

Other names: ethylbenzene dehydrogenase; ethylbenzene:(acceptor) oxidoreductase

Systematic name: ethylbenzene:acceptor oxidoreductase

Comments: Involved in the anaerobic catabolism of ethylbenzene by denitrifying bacteria. Ethylbenzene is the preferred substrate; the enzyme from some strains oxidizes propylbenzene, 1-ethyl-4-fluorobenzene, 3-methylpent-2-ene and ethylidenecyclohexane. Toluene is not oxidized. p-Benzoquinone or ferrocenium can act as electron acceptor. Contains molybdopterin, [4Fe-4S] clusters and heme b.

Links to other databases: BRENDA, EAWAG-BBD, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 372947-56-3


1. Kniemeyer, O. and Heider, J. Ethylbenzene dehydrogenase, a novel hydrocarbon-oxidising molybdenum/iron-sulfur/heme enzyme. J. Biol. Chem. 276 (2001) 21381-21386. [PMID: 11294876]

2. Johnson, H.A., Pelletier, D.A. and Spormann, A.M. Isolation and characterisation of anaerobic ethylbenzene dehydrogenase, a novel Mo-Fe-S enzyme. J. Bacteriol. 183 (2001) 4536-4542. [PMID: 11443088]

[EC created 2001]

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