IUBMB Enzyme Nomenclature


Accepted name: ferredoxin—NADP+ reductase

Reaction: 2 reduced ferredoxin + NADP+ + H+ = 2 oxidized ferredoxin + NADPH

For diagram of reaction, click here

Other name(s): ferredoxin-nicotinamide adenine dinucleotide phosphate reductase; ferredoxin-NADP+ reductase; TPNH-ferredoxin reductase; ferredoxin-NADP+ oxidoreductase; NADP+:ferredoxin oxidoreductase; ferredoxin-TPN reductase; ferredoxin-NADP+-oxidoreductase; NADPH:ferredoxin oxidoreductase; ferredoxin-nicotinamide-adenine dinucleotide phosphate (oxidized) reductase

Systematic name: ferredoxin:NADP+ oxidoreductase

Comments: A flavoprotein (FAD). In chloroplasts and cyanobacteria the enzyme acts on plant-type [2Fe-2S] ferredoxins, but in other bacteria it can also reduce bacterial 2[4Fe-4S] ferredoxins and flavodoxin.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9029-33-8


1. Shin, M., Tagawa, K. and Arnon, D.I. Crystallization of ferredoxin-TPN reductase and its role in the photosynthetic apparatus of chloroplasts. Biochem. Z. 338 (1963) 84-96.

2. Knaff, D.B. and Hirasawa, M. Ferredoxin-dependent chloroplast enzymes. Biochim. Biophys. Acta 1056 (1991) 93-125. [PMID: 1671559]

3. Karplus, P.A., Daniels, M.J. and Herriott, J.R. Atomic structure of ferredoxin-NADP+ reductase: prototype for a structurally novel flavoenzyme family. Science 251 (1991) 60-66. [PMID: 1986412]

4. Morales, R., Charon, M.H., Kachalova, G., Serre, L., Medina, M., Gomez-Moreno, C. and Frey, M. A redox-dependent interaction between two electron-transfer partners involved in photosynthesis. EMBO Rep. 1 (2000) 271-276. [PMID: 11256611]

[EC created 1965 as EC, transferred 1972 as EC, transferred 1978 to EC, part transferred 2012 to EC, modified 2012]

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