IUBMB Enzyme Nomenclature


Accepted name: [amino group carrier protein]-6-phospho-L-2-aminoadipate reductase

Reaction: an [amino group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + phosphate + NADP+ = an [amino group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + NADPH + H+

Other name(s): lysY (gene name)

Systematic name: [amino group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine:NADP+ 5-oxidoreductase (phosphorylating)

Comments: The enzyme participates in an L-lysine biosynthesis in certain species of archaea and bacteria.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Nishida, H., Nishiyama, M., Kobashi, N., Kosuge, T., Hoshino, T. and Yamane, H. A prokaryotic gene cluster involved in synthesis of lysine through the amino adipate pathway: a key to the evolution of amino acid biosynthesis. Genome Res 9 (1999) 1175-1183. [PMID: 10613839]

2. Horie, A., Tomita, T., Saiki, A., Kono, H., Taka, H., Mineki, R., Fujimura, T., Nishiyama, C., Kuzuyama, T. and Nishiyama, M. Discovery of proteinaceous N-modification in lysine biosynthesis of Thermus thermophilus. Nat. Chem. Biol. 5 (2009) 673-679. [PMID: 19620981]

3. Shimizu, T., Tomita, T., Kuzuyama, T. and Nishiyama, M. Crystal Structure of the LysY.LysW Complex from Thermus thermophilus. J. Biol. Chem 291 (2016) 9948-9959. [PMID: 26966182]

[EC created 2019]

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