Reaction: a long-chain acyl-CoA + 2 NADH + 2 H+ = a long-chain alcohol + 2 NAD+ + CoA
Glossary: a long-chain acyl-CoA = an acyl-CoA thioester where the acyl chain contains 13 to 22 carbon atoms.
Other name(s): FAR (gene name); long-chain acyl-CoA:NADH reductase
Systematic name: NADH:long-chain acyl-CoA reductase
Comments: The enzyme has been characterized from the photosynthetic flagellate Euglena gracilis. The alcohol is formed by a four-electron reduction of fatty acyl-CoA by NADH. Although the reaction proceeds through an aldehyde intermediate, a free aldehyde is not released. cf. EC 1.2.1.84, alcohol-forming fatty acyl-CoA reductase (NADPH).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Kolattukudy, P.E. Reduction of fatty acids to alcohols by cell-free preparations of Euglena gracilis. Biochemistry 9 (1970) 1095-1102. [PMID: 4313936]
2. Teerawanichpan, P. and Qiu, X. Fatty acyl-CoA reductase and wax synthase from Euglena gracilis in the biosynthesis of medium-chain wax esters. Lipids 45 (2010) 263-273. [PMID: 20195781]