IUBMB Enzyme Nomenclature


Accepted name: malonate-semialdehyde dehydrogenase (acetylating)

Reaction: 3-oxopropanoate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H

Other name(s): malonic semialdehyde oxidative decarboxylase

Systematic name: 3-oxopropanoate:NAD(P)+ oxidoreductase (decarboxylating, CoA-acetylating)

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 9028-97-1


1. Hayaishi, O., Nishizuka, Y., Tatibana, M., Takeshita, M. and Kuno, S. Enzymatic studies on the metabolism of β-alanine. J. Biol. Chem. 236 (1961) 781-790.

2. Jakoby, W.B. Aldehyde dehydrogenase. In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 203-221.

3. Yamada, E.W. and Jakoby, W.B. Aldehyde oxidation. V. Direct conversion of malonic semialdehyde to acetyl-coenzyme A. J. Biol. Chem. 235 (1960) 589-594.

[EC created 1965]

Return to EC 1.2.1 home page
Return to EC 1.2 home page
Return to EC 1 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page