IUBMB Enzyme Nomenclature


Accepted name: cinnamoyl-CoA reductase

Reaction: cinnamaldehyde + CoA + NADP+ = cinnamoyl-CoA + NADPH + H+

Other name(s): feruloyl-CoA reductase; cinnamoyl-coenzyme A reductase; ferulyl-CoA reductase; feruloyl coenzyme A reductase; p-hydroxycinnamoyl coenzyme A reductase; cinnamoyl-CoA:NADPH reductase

Systematic name: cinnamaldehyde:NADP+ oxidoreductase (CoA-cinnamoylating)

Comments: Acts also on a number of substituted cinnamoyl esters of coenzyme A.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 59929-39-4


1. Gross, G.G. and Kreiten, W. Reduction of coenzyme A thioesters of cinnamic acids with an enzyme preparation from lignifying tissue of Forsythia. FEBS Lett. 54 (1975) 259-262. [PMID: 236926]

2. Sarni, F., Grand, C. and Baudet, A.M. Purification and properties of cinnamoyl-CoA reductase and cinnamyl alcohol dehydrogenase from poplar stems (Populus X euramericana). Eur. J. Biochem. 139 (1984) 259-265. [PMID: 6365550]

3. Wengenmayer, H., Ebel, J. and Grisebach, H. Enzymic synthesis of lignin precursors. Purification and properties of a cinnamoyl-CoA: NADPH reductase from cell suspension cultures of soybean (Glycinemax). Eur. J. Biochem. 65 (1976) 529-536. [PMID: 7454]

[EC created 1978]

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