IUBMB Enzyme Nomenclature


Accepted name: pyruvate dehydrogenase (NADP+)

Reaction: pyruvate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH

Other name(s): pyruvate dehydrogenase (NADP)

Systematic name: pyruvate:NADP+ 2-oxidoreductase (CoA-acetylating)

Comments: The Euglena enzyme can also use FAD or methyl viologen as acceptor, more slowly. The enzyme is inhibited by oxygen.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 93389-35-6


1. Inui, H., Miyatake, K., Nakano, Y. and Kitaoka, S. Occurrence of oxygen-sensitive, NADP+-dependent pyruvate dehydrogenase in mitochondria of Euglena gracilis. J. Biochem. (Tokyo) 96 (1984) 931-934. [PMID: 6438078]

2. Inui, H., Ono, K., Miyatake, K., Nakano, Y. and Kitaoka, S. Purification and characterization of pyruvate:NADP+ oxidoreductase in Euglena gracilis. J. Biol. Chem. 262 (1987) 9130-9135. [PMID: 3110154]

[EC created 1989]

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