IUBMB Enzyme Nomenclature


Accepted name: oxoglutarate dehydrogenase (NADP+)

Reaction: 2-oxoglutarate + CoA + NADP+ = succinyl-CoA + CO2 + NADPH

Other name(s): oxoglutarate dehydrogenase (NADP)

Systematic name: 2-oxoglutarate:NADP+ 2-oxidoreductase (CoA-succinylating)

Comments: The Euglena enzyme can also use NAD+ as acceptor, but more slowly.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 126469-85-0


1. Inui, H., Miyatake, K., Nakano, Y. and Kitaoka, S. Occurrence of oxygen-sensitive, NADP+-dependent pyruvate dehydrogenase in mitochondria of Euglena gracilis. J. Biochem. (Tokyo) 96 (1984) 931-934. [PMID: 6438078]

[EC created 1989]

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