IUBMB Enzyme Nomenclature


Accepted name: 4-hydroxymuconic-semialdehyde dehydrogenase

Reaction: 4-hydroxymuconic semialdehyde + NAD+ + H2O = maleylacetate + NADH + 2 H+

For diagram of reaction click here.

Systematic name: 4-hydroxymuconic-semialdehyde:NAD+ oxidoreductase

Comments: Involved in the 4-nitrophenol degradation pathway.

Links to other databases: BRENDA, EAWAG-BBD, EXPASY, KEGG, Metacyc, CAS registry number:


1. Spain, J.C. and Gibson, D.T. Pathway for bioremediation of p-nitrophenol in a Moraxella sp. Appl. Environ. Microbiol. 57 (1991) 812-819.

[EC created 2000]

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