IUBMB Enzyme Nomenclature


Accepted name: fluoroacetaldehyde dehydrogenase

Reaction: fluoroacetaldehyde + NAD+ + H2O = fluoroacetate + NADH + 2 H+

Systematic name: fluoroacetaldehyde:NAD+ oxidoreductase

Comments: The enzyme from Streptomyces cattleya has a high affinity for fluoroacetate and glycolaldehyde but not for acetaldehyde.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 387336-50-7


1. Murphy, C.D., Moss, S.J. and O'Hagan, D. Isolation of an aldehyde dehydrogenase involved in the oxidation of fluoroacetaldehyde to fluoroacetate in Streptomyces cattleya. Appl. Environ. Microbiol. 67 (2001) 4919-4921. [PMID: 11571203]

2. Murphy, C.D., Schaffrath, C. and O'Hagan, D. Fluorinated natural products: the biosynthesis of fluoroacetate and 4-fluorothreonine in Streptomyces cattleya. Chemosphere 52 (2003) 455-461. [PMID: 12738270]

[EC created 2003]

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