IUBMB Enzyme Nomenclature


Accepted name: 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase (NADP+)

Reaction: 3,4-didehydroadipyl-CoA semialdehyde + NADP+ + H2O = 3,4-didehydroadipyl-CoA + NADPH + H+

For diagram of reaction click here.

Other name(s): BoxD; 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase

Systematic name: 3,4-didehydroadipyl-CoA semialdehyde:NADP+ oxidoreductase

Comments: This enzyme catalyses a step in the aerobic benzoyl-coenzyme A catabolic pathway in Azoarcus evansii and Burkholderia xenovorans.

Links to other databases: BRENDA, EAWAG-BBD, EXPASY, KEGG, Metacyc, CAS registry number:


1. Gescher, J., Ismail, W., Olgeschlager, E., Eisenreich, W., Worth, J. and Fuchs, G. Aerobic benzoyl-coenzyme A (CoA) catabolic pathway in Azoarcus evansii: conversion of ring cleavage product by 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase. J. Bacteriol. 188 (2006) 2919-2927. [PMID: 16585753]

2. Bains, J. and Boulanger, M.J. Structural and biochemical characterization of a novel aldehyde dehydrogenase encoded by the benzoate oxidation pathway in Burkholderia xenovorans LB400. J. Mol. Biol. 379 (2008) 597-608. [PMID: 18462753]

[EC created 2010]

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