IUBMB Enzyme Nomenclature


Accepted name: 2-formylbenzoate dehydrogenase

Reaction: 2-formylbenzoate + NAD+ + H2O = o-phthalic acid + NADH + H+

Glossary: o-phthalic acid = benzene-1,2-dicarboxylic acid
2-formylbenzoate = 2-carboxybenzaldehyde

Other name(s): 2-carboxybenzaldehyde dehydrogenase; 2CBAL dehydrogenase; PhdK

Systematic name: 2-formylbenzoate:NAD+ oxidoreductase

Comments: The enzyme is involved in phenanthrene degradation.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Iwabuchi, T. and Harayama, S. Biochemical and genetic characterization of 2-carboxybenzaldehyde dehydrogenase, an enzyme involved in phenanthrene degradation by Nocardioides sp. strain KP7. J. Bacteriol. 179 (1997) 6488-6494. [PMID: 9335300]

2. Kiyohara, H., Nagao, K. and Yano, K. Isolation and some properties of NAD-linked 2-carboxybenzaldehyde dehydrogenase in Alcaligenes faecalis AFK 2 grown on phenanthrene. J. Gen. Appl. Microbiol. 27 (1981) 443-455.

[EC created 2010]

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