IUBMB Enzyme Nomenclature


Accepted name: β-apo-4'-carotenal dehydrogenase

Reaction: 4'-apo-β,ψ-caroten-4'-al + NAD+ + H2O = neurosporaxanthin + NADH + 2 H+

For diagram of reaction, click here

Glossary: neurosporaxanthin = 4'-apo-β,ψ-caroten-4'-oic acid

Other name(s): β-apo-4'-carotenal oxygenase; YLO-1; carD (gene name)

Systematic name: 4'-apo-β,ψ-carotenal:NAD+ oxidoreductase

Comments: Neurosporaxanthin is responsible for the orange color of of Neurospora.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Estrada, A.F., Youssar, L., Scherzinger, D., Al-Babili, S. and Avalos, J. The ylo-1 gene encodes an aldehyde dehydrogenase responsible for the last reaction in the Neurospora carotenoid pathway. Mol. Microbiol. 69 (2008) 1207-1220. [PMID: 18627463]

2. Diaz-Sanchez, V., Estrada, A.F., Trautmann, D., Al-Babili, S. and Avalos, J. The gene carD encodes the aldehyde dehydrogenase responsible for neurosporaxanthin biosynthesis in Fusarium fujikuroi. FEBS J. 278 (2011) 3164-3176. [PMID: 21749649]

[EC created 2011, modified 2023]

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