IUBMB Enzyme Nomenclature


Accepted name: 2-hydroxy-2-methylpropanal dehydrogenase

Reaction: 2-hydroxy-2-methylpropanal + NAD+ + H2O = 2-hydroxyisobutanoate + NADH + H+

Other name(s): mpdC (gene name)

Systematic name: 2-hydroxy-2-methylpropanal:NAD+ oxidoreductase

Comments: This bacterial enzyme is involved in the degradation pathways of the alkene 2-methylpropene and the fuel oxygenate methyl tert-butyl ether (MTBE), a widely occurring groundwater contaminant.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Lopes Ferreira, N., Labbe, D., Monot, F., Fayolle-Guichard, F. and Greer, C.W. Genes involved in the methyl tert-butyl ether (MTBE) metabolic pathway of Mycobacterium austroafricanum IFP 2012. Microbiology 152 (2006) 1361-1374. [PMID: 16622053]

[EC created 2016]

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