IUBMB Enzyme Nomenclature


Accepted name: 4-(γ-glutamylamino)butanal dehydrogenase

Reaction: 4-(γ-L-glutamylamino)butanal + NAD(P)+ + H2O = 4-(γ-L-glutamylamino)butanoate + NAD(P)H + H+

Other name(s): puuC (gene name)

Systematic name: 4-(γ-L-glutamylamino)butanal:NAD(P)+ oxidoreductase

Comments: The enzyme, characterized from the bacterium Escherichia coli, is involved in a putrescine catabolic pathway. It has a broad substrate range, and can also catalyse the activities of EC, aminobutyraldehyde dehydrogenase, and EC, succinate-semialdehyde dehydrogenase (NAD+).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Kurihara, S., Oda, S., Kato, K., Kim, H.G., Koyanagi, T., Kumagai, H. and Suzuki, H. A novel putrescine utilization pathway involves γ-glutamylated intermediates of Escherichia coli K-12. J. Biol. Chem. 280 (2005) 4602-4608. [PMID: 15590624]

2. Jo, J.E., Mohan Raj, S., Rathnasingh, C., Selvakumar, E., Jung, W.C. and Park, S. Cloning, expression, and characterization of an aldehyde dehydrogenase from Escherichia coli K-12 that utilizes 3-hydroxypropionaldehyde as a substrate. Appl. Microbiol. Biotechnol. 81 (2008) 51-60. [PMID: 18668238]

3. Schneider, B.L. and Reitzer, L. Pathway and enzyme redundancy in putrescine catabolism in Escherichia coli. J. Bacteriol. 194 (2012) 4080-4088. [PMID: 22636776]

[EC created 2017]

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