IUBMB Enzyme Nomenclature


Accepted name: 4,4'-diapolycopenoate synthase

Reaction: (1) 4,4'-diapolycopen-4-al + H2O + acceptor = 4,4'-diapolycopen-4-oate + reduced acceptor
(2) 4,4'-diapolycopene-4,4'-dial + 2 H2O + 2 acceptor = 4,4'-diapolycopene-4,4'-dioate + 2 reduced acceptor

For diagram of reaction click here

Other name(s): crtNc; 4,4'-diapolycopenealdehyde oxidase (misleading)

Systematic name: 4,4'-diapolycopen-4-al,donor:oxygen oxidoreductase (4,4'-diapolycopen-4-oate-forming)

Comments: The enzyme has been described from the bacteria Methylomonas sp. 16a and Bacillus indicus.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Tao, L., Schenzle, A., Odom, J.M. and Cheng, Q. Novel carotenoid oxidase involved in biosynthesis of 4,4'-diapolycopene dialdehyde. Appl. Environ. Microbiol. 71 (2005) 3294-3301. [PMID: 15933032]

2. Steiger, S., Perez-Fons, L., Cutting, S.M., Fraser, P.D. and Sandmann, G. Annotation and functional assignment of the genes for the C30 carotenoid pathways from the genomes of two bacteria: Bacillus indicus and Bacillus firmus. Microbiology 161 (2015) 194-202. [PMID: 25326460]

[EC created 2017]

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