IUBMB Enzyme Nomenclature


Accepted name: glyceraldehyde dehydrogenase (FAD-containing)

Reaction: D-glyceraldehyde + H2O + acceptor = D-glycerate + reduced acceptor

For diagram of reaction click here.

Other name(s): glyceraldehyde oxidoreductase

Systematic name: D-glyceraldehyde:acceptor oxidoreductase (FAD-containing)

Comments: The enzyme from the archaeon Sulfolobus acidocaldarius catalyses the oxidation of D-glyceraldehyde in the nonphosphorylative Entner-Doudoroff pathway. With 2,6-dichlorophenolindophenol as artificial electron acceptor, the enzyme shows a broad substrate range, but is most active with D-glyceraldehyde. It is not known which acceptor is utilized in vivo. The iron-sulfur protein contains FAD and molybdopterin guanine dinucleotide.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Kardinahl, S., Schmidt, C.L., Hansen, T., Anemuller, S., Petersen, A. and Schafer, G. The strict molybdate-dependence of glucose-degradation by the thermoacidophile Sulfolobus acidocaldarius reveals the first crenarchaeotic molybdenum containing enzyme—an aldehyde oxidoreductase. Eur. J. Biochem. 260 (1999) 540-548. [PMID: 10095793]

[EC created 2013]

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