IUBMB Enzyme Nomenclature


Accepted name: phosphonate dehydrogenase

Reaction: phosphonate + NAD+ + H2O = phosphate + NADH + H+

Other name(s): NAD:phosphite oxidoreductase; phosphite dehydrogenase

Systematic name: phosphonate:NAD+ oxidoreductase

Comments: NADP+ is a poor substitute for NAD+ in the enzyme from Pseudomonas stutzeri WM88.

Links to other databases: BRENDA, EAWAG-BBD, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9031-35-0


1. Costas, A.M.G., White, A.K. and Metcalf, W.W. Purification and characterization of a novel phosphorus-oxidizing enzyme from Pseudomonas stutzeri WM88. J. Biol. Chem. 276 (2001) 17429-17436. [PMID: 11278981]

2. Vrtis, J.M., White, A.K., Metcalf, W.W. and van der Donk, W.A. Phosphite dehydrogenase: An unusual phosphoryl transfer reaction. J. Am. Chem. Soc. 123 (2001) 2672-2673. [PMID: 11456941]

[EC created 2001]

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