IUBMB Enzyme Nomenclature


Accepted name: mycoredoxin

Reaction: arseno-mycothiol + mycoredoxin = arsenite + mycothiol-mycoredoxin disulfide

Glossary: mycothiol = 1-O-[2-(N2-acetyl-L-cysteinamido)-2-deoxy-α-D-glucopyranosyl]-1D-myo-inositol

Other name(s): Mrx1; MrxI

Systematic name: arseno-mycothiol:mycoredoxin oxidoreductase

Comments: Reduction of arsenate is part of a defense mechanism of the cell against toxic arsenate. The substrate arseno-mycothiol is formed by EC (arsenate:mycothiol transferase). A second mycothiol recycles mycoredoxin and forms mycothione.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Ordonez, E., Van Belle, K., Roos, G., De Galan, S., Letek, M., Gil, J.A., Wyns, L., Mateos, L.M. and Messens, J. Arsenate reductase, mycothiol, and mycoredoxin concert thiol/disulfide exchange. J. Biol. Chem. 284 (2009) 15107-15116. [PMID: 19286650]

[EC created 2010]

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