Reaction: L-tyrosine + 2 NADP+ + 2 iodide = 3,5-diiodo-L-tyrosine + 2 NADPH + 2 H+ (overall reaction)
(1a) L-tyrosine + NADP+ + iodide = 3-iodo-L-tyrosine + NADPH + H+
(1b) 3-iodo-L-tyrosine + NADP+ + iodide = 3,5-diiodo-L-tyrosine + NADPH + H+
Other name(s): iodotyrosine dehalogenase 1; DEHAL1
Systematic name: L-tyrosine,iodide:NADP+ oxidoreductase (iodinating)
Comments: The enzyme activity has only been demonstrated in the direction of 3-deiodination. Present in a transmembrane flavoprotein. Requires FMN.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number:
References:
1. Rosenberg, I.N. Purification of iodotyrosine deiodinase from bovine thyroid. Metabolism 19 (1970) 785-798. [PMID: 4394169]
2. Gnidehou, S., Caillou, B., Talbot, M., Ohayon, R., Kaniewski, J., Noel-Hudson, M.S., Morand, S., Agnangji, D., Sezan, A., Courtin, F., Virion, A. and Dupuy, C. Iodotyrosine dehalogenase 1 (DEHAL1) is a transmembrane protein involved in the recycling of iodide close to the thyroglobulin iodination site. FASEB J. 18 (2004) 1574-1576. [PMID: 15289438]
3. Friedman, J.E., Watson, J.A., Jr., Lam, D.W. and Rokita, S.E. Iodotyrosine deiodinase is the first mammalian member of the NADH oxidase/flavin reductase superfamily. J. Biol. Chem. 281 (2006) 2812-2819. [PMID: 16316988]
4. Thomas, S.R., McTamney, P.M., Adler, J.M., Laronde-Leblanc, N. and Rokita, S.E. Crystal structure of iodotyrosine deiodinase, a novel flavoprotein responsible for iodide salvage in thyroid glands. J. Biol. Chem. 284 (2009) 19659-19667. [PMID: 19436071]