Reaction: stemmadenine acetate + O2 = precondylocarpine acetate + H2O2
For diagram of reaction, click here
Other name(s): PAS (gene name)
Systematic name: stemmadenine acetate:oxygen oxidoreductase
Comments: The enzyme, characterized from the plant Catharanthus roseus (Madagascar periwinkle), participates in a pathway that leads to the production of a number of monoterpene alkaloids, as well as the bisindole alkaloids vinblastine and vincristine, which are used as anticancer drugs. The enzyme is similar to berberine bridge enzymes such as EC 1.21.3.3, reticuline oxidase, and requires an FAD cofactor.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Caputi, L., Franke, J., Farrow, S.C., Chung, K., Payne, R.ME., Nguyen, T.D., Dang, T.T., Soares Teto Carqueijeiro, I., Koudounas, K., Duge de Bernonville, T., Ameyaw, B., Jones, D.M., Vieira, I.JC., Courdavault, V. and O'Connor, S.E. Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle. Science 360 (2018) 1235-1239. [PMID: 29724909]